UBE1L

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]

UBA7
Identifiers
Aliases	UBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7
External IDs	OMIM: 191325 MGI: 1349462 HomoloGene: 2502 GeneCards: UBA7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,805,209 bp[1] End 49,813,953 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 59.07 cM Start 107,975,505 bp[2] End 107,984,060 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATP binding • ISG15 activating enzyme activity • nucleotide binding • ubiquitin-like modifier activating enzyme activity • ligase activity • GO:0001948 protein binding • ubiquitin-protein transferase activity • ubiquitin activating enzyme activity Cellular component • nucleoplasm • cytosol • cytoplasm • cell nucleus Biological process • negative regulation of type I interferon production • ISG15-protein conjugation • cellular protein modification process • protein ubiquitination • modification-dependent protein catabolic process • ubiquitin-dependent protein catabolic process • cellular response to DNA damage stimulus • protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7318	74153
Ensembl	ENSG00000182179	ENSMUSG00000032596
UniProt	P41226	n/a
RefSeq (mRNA)	NM_003335	NM_023738
RefSeq (protein)	NP_003326	n/a
Location (UCSC)	Chr 3: 49.81 – 49.81 Mb	Chr 9: 107.98 – 107.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000182179 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032596 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
6. "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading

• Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer". Cancer Res. 52 (6): 1536–41. PMID 1311632.
• Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene". Gene Expr. 4 (3): 163–75. PMID 7734949.
• McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines". Int. J. Cancer. 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
• Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
• Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
• Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.