DNAJB6

DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.[5][6][7]

DNAJB6
Identifiers
AliasesDNAJB6, Dnajb6, Mrj, mDj4, DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MSJ-1, DnaJ heat shock protein family (Hsp40) member B6, LGMDD1
External IDsOMIM: 611332 MGI: 1344381 HomoloGene: 38058 GeneCards: DNAJB6
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q36.3Start157,335,381 bp[1]
End157,417,439 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10049

23950

Ensembl

ENSG00000105993

ENSMUSG00000029131

UniProt

O75190

O54946

RefSeq (mRNA)

NM_005494
NM_058246
NM_001363676

RefSeq (protein)

NP_005485
NP_490647
NP_001350605

Location (UCSC)Chr 7: 157.34 – 157.42 MbChr 5: 29.74 – 29.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[7]

Interactions

DNAJB6 has been shown to interact with Keratin 18.[8] It has been also shown that the aggregation of Aβ42 (a process involved in e.g. Alzheimer's disease) is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide.[9]

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References
  1. GRCh38: Ensembl release 89: ENSG00000105993 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029131 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seki N, Hattori A, Hayashi A, Kozuma S, Miyajima N, Saito T (June 1999). "Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family". J Hum Genet. 44 (3): 185–9. doi:10.1007/s100380050139. PMID 10319584.
  6. Pei L (March 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J Biol Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854.
  7. "Entrez Gene: DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6".
  8. Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M (2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. PMID 10954706.
  9. Månsson, C; Arosio, P; Hussein, R; Kampinga, H H; Hashem, R M; Boelens, W C; Emanuelsson, C (2014). "Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation". J. Biol. Chem. 289 (45): 31066–76. doi:10.1074/jbc.M114.595124. PMC 4223311. PMID 25217638.

Further reading
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