BIRC6

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.[5][6]

BIRC6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CEG
Identifiers
Aliases	BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs	OMIM: 605638 MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 32,357,028 bp[1] End 32,618,899 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 74,528,295 bp[2] End 74,703,356 bp[2]
Gene ontology Molecular function • peptidase inhibitor activity • cysteine-type endopeptidase inhibitor activity • ubiquitin-protein transferase activity • GO:0001948 protein binding • ubiquitin conjugating enzyme activity • transferase activity Cellular component • cytoplasm • endosome • spindle pole • membrane • microtubule organizing center • trans-Golgi network • cytoskeleton • Golgi apparatus • intracellular membrane-bounded organelle • midbody • Flemming body • cell nucleus Biological process • negative regulation of peptidase activity • spongiotrophoblast layer development • regulation of cytokinesis • placentation • labyrinthine layer development • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • cell division • protein phosphorylation • regulation of cell proliferation • protein ubiquitination • positive regulation of cell proliferation • cell cycle • apoptotic process • negative regulation of endopeptidase activity • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57448	12211
Ensembl	ENSG00000115760	ENSMUSG00000024073
UniProt	Q9NR09	O88738
RefSeq (mRNA)	NM_016252 NM_001378125	NM_007566
RefSeq (protein)	NP_057336 NP_001365054	NP_031592
Location (UCSC)	Chr 2: 32.36 – 32.62 Mb	Chr 17: 74.53 – 74.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[6]

Interactions

BIRC6 has been shown to interact with KIF23.[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology[9]).

References

1. GRCh38: Ensembl release 89: ENSG00000115760 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024073 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
6. "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
7. Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi:10.1016/j.cell.2008.01.012. PMID 18329369.
8. "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
9. "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links

• Human BIRC6 genome location and BIRC6 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
• Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase". Mol. Cell. 14 (6): 801–11. doi:10.1016/j.molcel.2004.05.018. PMID 15200957.
• Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255.
• Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
• Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9". J. Biol. Chem. 280 (1): 174–82. doi:10.1074/jbc.M411430200. PMID 15507451.