DNAJB4

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.[5][6][7]

DNAJB4
Identifiers
Aliases	DNAJB4, DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
External IDs	OMIM: 611327 MGI: 1914285 HomoloGene: 100610 GeneCards: DNAJB4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 77,979,175 bp[1] End 78,017,964 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 152,178,511 bp[2] End 152,210,302 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • unfolded protein binding • chaperone binding • GO:0001948 protein binding • ATPase activator activity Cellular component • cytosol • membrane • cytoplasm • nucleoplasm • cell membrane Biological process • response to unfolded protein • response to heat • protein folding • positive regulation of ATPase activity • negative regulation of transcription from RNA polymerase II promoter • chaperone mediated protein folding requiring cofactor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11080	67035
Ensembl	ENSG00000162616	ENSMUSG00000028035
UniProt	Q9UDY4	Q9D832
RefSeq (mRNA)	NM_007034 NM_001317099 NM_001317100 NM_001317101 NM_001317102 NM_001317103	NM_025926 NM_027287 NM_001356363 NM_001356364
RefSeq (protein)	NP_001304028 NP_001304029 NP_001304030 NP_001304031 NP_001304032 NP_008965	NP_080202 NP_081563 NP_001343292 NP_001343293
Location (UCSC)	Chr 1: 77.98 – 78.02 Mb	Chr 3: 152.18 – 152.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000162616 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028035 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.
6. Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. ISSN 1466-1268. PMC 312896. PMID 11147971.
7. "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Borges JC, Fischer H, Craievich AF, Ramos CH (2005). "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures". J. Biol. Chem. 280 (14): 13671–81. doi:10.1074/jbc.M408349200. PMID 15661747.
• Wang CC, Tsai MF, Hong TM, et al. (2005). "The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117.
• Ancevska-Taneva N, Onoprishvili I, Andria ML, et al. (2006). "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor". Brain Res. 1081 (1): 28–33. doi:10.1016/j.brainres.2006.01.125. PMID 16542645.
• Tsai MF, Wang CC, Chang GC, et al. (2006). "A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma". J. Natl. Cancer Inst. 98 (12): 825–38. doi:10.1093/jnci/djj229. PMID 16788156.