UBE2O

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.[5][6][7]

UBE2O
Identifiers
Aliases	UBE2O, E2-230K, ubiquitin conjugating enzyme E2 O
External IDs	OMIM: 617649 MGI: 2444266 HomoloGene: 11113 GeneCards: UBE2O
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,389,456 bp[1] End 76,453,152 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,537,740 bp[2] End 116,581,447 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • GO:0001948 protein binding • ATP binding • ubiquitin conjugating enzyme activity • ubiquitin protein ligase binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin-protein transferase activity • RNA binding Cellular component • cytoplasm • cell nucleus • cytosol • nuclear body Biological process • positive regulation of BMP signaling pathway • protein K63-linked ubiquitination • retrograde transport, endosome to Golgi • protein monoubiquitination • protein ubiquitination • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63893	217342
Ensembl	ENSG00000175931	ENSMUSG00000020802
UniProt	Q9C0C9	Q6ZPJ3
RefSeq (mRNA)	NM_022066	NM_173755
RefSeq (protein)	NP_071349	NP_776116
Location (UCSC)	Chr 17: 76.39 – 76.45 Mb	Chr 11: 116.54 – 116.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175931 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020802 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokota T, Nagai H, Harada H, Mine N, Terada Y, Fujiwara H, Yabe A, Miyazaki K, Emi M (Apr 2001). "Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k". Gene. 267 (1): 95–100. doi:10.1016/S0378-1119(01)00407-3. PMID 11311559.
6. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
7. "Entrez Gene: UBE2O ubiquitin-conjugating enzyme E2O".
8. Nguyen AT, Prado MA, et al. (2017). "UBE2O remodels the proteome during terminal erythroid differentiation". Science. 357 (6350): eaan0218. doi:10.1126/science.aan0218. PMC 5812729. PMID 28774900.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.