Sarcalumenin

SRL
Identifiers
Aliases	SRL, entrez:6345, sarcalumenin, SAR
External IDs	OMIM: 604992 MGI: 2146620 HomoloGene: 45500 GeneCards: SRL
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	4,242,080 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	4,541,816 bp[2]
Gene ontology
Molecular function	• GTP binding;
Cellular component	• sarcoplasmic reticulum; • sarcoplasmic reticulum lumen;
Biological process	• store-operated calcium entry; • response to muscle activity involved in regulation of muscle adaptation;
	Sources:Amigo / QuickGO
Orthologs
	6345
	106393
	ENSG00000185739
	ENSMUSG00000022519
	Q86TD4
	Q7TQ48
	NM_001098814; NM_001323667; NM_001323668
	NM_175347; NM_001347162; NM_001361474
	NP_001092284; NP_001310596; NP_001310597
	NP_001334091; NP_780556; NP_001348403
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcalumenin is a protein that in humans is encoded by the SAR gene.[5][6]

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.[7] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.[8] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.[7]

References

GRCh38: Ensembl release 89: ENSG00000185739 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022519 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. doi:10.1073/pnas.86.16.6047. PMC 297772. PMID 2762314.
Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576-82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.
Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.

External links

sarcalumenin at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185739 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022519 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2762314-5] Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. doi:10.1073/pnas.86.16.6047. PMC 297772. PMID 2762314.

[pmid8681137-6] Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.

[Jiao_2009-7] Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576-82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.

[pmid15569689-8] Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.