Visinin-like protein 1

Visinin-like protein 1 is a protein that in humans is encoded by the VSNL1 gene.[5][6][7]

VSNL1
Identifiers
AliasesVSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, visinin like 1
External IDsOMIM: 600817 MGI: 1349453 HomoloGene: 2542 GeneCards: VSNL1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p24.2Start17,539,126 bp[1]
End17,657,018 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7447

26950

Ensembl

ENSG00000163032

ENSMUSG00000054459

UniProt

P62760

P62761

RefSeq (mRNA)

NM_003385

NM_012038
NM_001378929

RefSeq (protein)

NP_003376
NP_001353732
NP_001353733
NP_001353734
NP_001353735

NP_036168
NP_001365858

Location (UCSC)Chr 2: 17.54 – 17.66 MbChr 12: 11.33 – 11.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins.[8]

The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163032 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Polymeropoulos MH, Ide S, Soares MB, Lennon GG (Feb 1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.
  6. Kose A, Ito A, Saito N, Tanaka C (Oct 1990). "Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus". Brain Res. 518 (1–2): 209–17. doi:10.1016/0006-8993(90)90974-G. PMID 2202488.
  7. "Entrez Gene: VSNL1 visinin-like 1".
  8. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

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