CALM2

Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.[3][4]

CALM2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2
External IDsOMIM: 114182 HomoloGene: 134804 GeneCards: CALM2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band2p21Start47,160,083 bp[1]
End47,176,921 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

805

n/a

Ensembl

ENSG00000143933

n/a

UniProt

P0DP23
P0DP24

n/a

RefSeq (mRNA)

NM_001305624
NM_001305625
NM_001305626
NM_001743

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 47.16 – 47.18 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Clinical significance

Mutations in CALM2 are associated to cardiac arrhythmias.[5]

Interactions

CALM2 has been shown to interact with AKAP9.[6][7]

gollark: Sure? I would move it to beside <#733816666089062511> but mobile.
gollark: Heavpoot is to be declared SCP-3125-A with immediate effect.
gollark: My tape download program now supports downloading big files without splitting them, via range requests, assuming they're served from a server which supports it: https://pastebin.com/LW9RFpmY (do `web2tape https://url.whatever range`)
gollark: Here is a similar thing for JSON. Note that it delegates out to an external JSON library for string escaping.```luafunction safe_json_serialize(x, prev) local t = type(x) if t == "number" then if x ~= x or x <= -math.huge or x >= math.huge then return tostring(x) end return string.format("%.14g", x) elseif t == "string" then return json.encode(x) elseif t == "table" then prev = prev or {} local as_array = true local max = 0 for k in pairs(x) do if type(k) ~= "number" then as_array = false break end if k > max then max = k end end if as_array then for i = 1, max do if x[i] == nil then as_array = false break end end end if as_array then local res = {} for i, v in ipairs(x) do table.insert(res, safe_json_serialize(v)) end return "["..table.concat(res, ",").."]" else local res = {} for k, v in pairs(x) do table.insert(res, json.encode(tostring(k)) .. ":" .. safe_json_serialize(v)) end return "{"..table.concat(res, ",").."}" end elseif t == "boolean" then return tostring(x) elseif x == nil then return "null" else return json.encode(tostring(x)) endend```
gollark: My tape shuffler thing from a while ago got changed round a bit. Apparently there's some demand for it, so I've improved the metadata format and written some documentation for it, and made the encoder work better by using file metadata instead of filenames and running tasks in parallel so it's much faster. The slightly updated code and docs are here: https://pastebin.com/SPyr8jrh. There are also people working on alternative playback/encoding software for the format for some reason.

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000143933 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".
  4. SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". J. Biol. Chem. 262 (34): 16663–70. PMID 2445749.
  5. Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL (2014). "Novel calmodulin mutations associated with congenital arrhythmia susceptibility". Circ Cardiovasc Genet. 7 (4): 466–74. doi:10.1161/CIRCGENETICS.113.000459. PMC 4140998. PMID 24917665.
  6. Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
  7. Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE (May 1993). "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3". Genomics. 16 (2): 461–5. doi:10.1006/geno.1993.1211. PMID 8314583.

Further reading


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