EFEMP2

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.[5][6][7]

EFEMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KL7
Identifiers
Aliases	EFEMP2, ARCL1B, FBLN4, MBP1, UPH1, EGF containing fibulin like extracellular matrix protein 2, EGF containing fibulin extracellular matrix protein 2
External IDs	OMIM: 604633 MGI: 1891209 HomoloGene: 32339 GeneCards: EFEMP2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,866,441 bp[1] End 65,873,592 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,473,954 bp[2] End 5,482,517 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • extracellular matrix structural constituent • GO:0001948 protein binding Cellular component • extracellular vesicle • extracellular region • basement membrane • extracellular exosome • extracellular • collagen-containing extracellular matrix Biological process • elastic fiber assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30008	58859
Ensembl	ENSG00000172638	ENSMUSG00000024909
UniProt	O95967	Q9WVJ9
RefSeq (mRNA)	NM_016938	NM_001164352 NM_021474 NM_001374680
RefSeq (protein)	NP_058634	NP_001157824 NP_067449 NP_001361609
Location (UCSC)	Chr 11: 65.87 – 65.87 Mb	Chr 19: 5.47 – 5.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.[7]

Interactions

EFEMP2 has been shown to interact with P53.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000172638 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024909 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giltay R, Timpl R, Kostka G (Feb 2000). "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4". Matrix Biol. 18 (5): 469–80. doi:10.1016/S0945-053X(99)00038-4. PMID 10601734.
6. Katsanis N, Venable S, Smith JR, Lupski JR (Sep 2000). "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13". Hum Genet. 106 (1): 66–72. doi:10.1007/s004390051011. PMID 10982184.
7. "Entrez Gene: EFEMP2 EGF-containing fibulin-like extracellular matrix protein 2".
8. Gallagher, W M; Argentini M; Sierra V; Bracco L; Debussche L; Conseiller E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882.

Further reading

• Gallagher WM, Argentini M, Sierra V, et al. (1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. PMID 10380882.
• Gallagher WM, Greene LM, Ryan MP, et al. (2001). "Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues". FEBS Lett. 489 (1): 59–66. doi:10.1016/S0014-5793(00)02389-9. PMID 11231014.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Xiang Y, Sekine T, Nakamura H, et al. (2006). "Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis". J. Immunol. 176 (5): 3196–204. doi:10.4049/jimmunol.176.5.3196. PMID 16493080.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
• Hucthagowder V, Sausgruber N, Kim KH, et al. (2006). "Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome". Am. J. Hum. Genet. 78 (6): 1075–80. doi:10.1086/504304. PMC 1474103. PMID 16685658.
• El-Hallous E, Sasaki T, Hubmacher D, et al. (2007). "Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin". J. Biol. Chem. 282 (12): 8935–46. doi:10.1074/jbc.M608204200. PMID 17255108.

External links

• GeneReview/NCBI/NIH/UW entry on EFEMP2-Related Cutis Laxa