SYT2

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.[5][6]

SYT2
Identifiers
Aliases	SYT2, SytII, CMS7, MYSPC, synaptotagmin 2
External IDs	OMIM: 600104 MGI: 99666 HomoloGene: 22516 GeneCards: SYT2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,590,596 bp[1] End 202,710,454 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 58.24 cM Start 134,646,677 bp[2] End 134,762,593 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • calcium ion binding • inositol 1,3,4,5 tetrakisphosphate binding • clathrin binding • syntaxin binding • GO:0001948 protein binding • calcium-dependent phospholipid binding • SNARE binding • phosphatidylserine binding Cellular component • cell junction • chromaffin granule membrane • synaptic vesicle • membrane • cytoplasmic vesicle • synapse • integral component of membrane • synaptic vesicle membrane • cell membrane • clathrin-coated vesicle membrane • axon • dense core granule • exocytic vesicle Biological process • synaptic vesicle endocytosis • cell differentiation • GO:0010554 neurotransmitter secretion • positive regulation of dendrite extension • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • membrane organization • regulation of dopamine secretion • synaptic vesicle exocytosis • vesicle-mediated transport • calcium ion regulated exocytosis • cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	127833	20980
Ensembl	ENSG00000143858	ENSMUSG00000026452
UniProt	Q8N9I0	P46097
RefSeq (mRNA)	NM_001136504 NM_177402	NM_009307 NM_001355726
RefSeq (protein)	NP_001129976 NP_796376	NP_033333 NP_001342655
Location (UCSC)	Chr 1: 202.59 – 202.71 Mb	Chr 1: 134.65 – 134.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143858 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026452 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232.
6. "Entrez Gene: SYT2 synaptotagmin II".

Further reading

• Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". The Journal of Biological Chemistry. 269 (46): 29206–11. PMID 7961887.
• Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells". The Journal of Experimental Medicine. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum". The Journal of Cell Biology. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
• Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
• Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Letters. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368.
• Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
• Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". The Journal of Biological Chemistry. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
• Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Molecular Cell. 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.