SYT7

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.[5][6]

SYT7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7
External IDsOMIM: 604146 MGI: 1859545 HomoloGene: 20889 GeneCards: SYT7
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.2Start61,513,714 bp[1]
End61,581,148 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9066

54525

Ensembl

ENSG00000011347

ENSMUSG00000024743

UniProt

O43581

Q9R0N7

RefSeq (mRNA)

NM_018801
NM_173067
NM_173068
NM_001373944

RefSeq (protein)

NP_061271
NP_775090
NP_775091

Location (UCSC)Chr 11: 61.51 – 61.58 MbChr 19: 10.39 – 10.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.[supplied by OMIM][6]

Interactions

SYT7 has been shown to interact with SYNCRIP.[7]

gollark: Wait, removing the weirding gadget? What's the replacement?
gollark: OR DO YOU?
gollark: Something like that, but it's not because of higher or lower gravity.
gollark: If you go deeper underwater, then the change in pressure isn't due to higher gravity - it's not significant enough of a change - but... more being above you, or something, so it's compressed more?
gollark: I mean, very slightly yes, but not significantly.

References

  1. GRCh38: Ensembl release 89: ENSG00000011347 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024743 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.
  6. "Entrez Gene: SYT7 synaptotagmin VII".
  7. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O43581 (Human Synaptotagmin-7) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB.


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