SYT13

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.[5][6]

SYT13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WFM
Identifiers
Aliases	SYT13, synaptotagmin 13
External IDs	OMIM: 607716 MGI: 1933945 HomoloGene: 10823 GeneCards: SYT13
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 45,240,302 bp[1] End 45,286,341 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 92,915,098 bp[2] End 92,956,058 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent phospholipid binding • clathrin binding • calcium ion binding • syntaxin binding • SNARE binding • phosphatidylserine binding Cellular component • integral component of membrane • integral component of plasma membrane • transport vesicle • intracellular membrane-bounded organelle • membrane • cell membrane • presynapse • synapse • exocytic vesicle Biological process • vesicle-mediated transport • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • regulation of dopamine secretion • synaptic vesicle exocytosis • calcium ion regulated exocytosis • cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57586	80976
Ensembl	ENSG00000019505	ENSMUSG00000027220
UniProt	Q7L8C5	Q9EQT6
RefSeq (mRNA)	NM_020826 NM_001247987	NM_030725
RefSeq (protein)	NP_001234916 NP_065877	NP_109650
Location (UCSC)	Chr 11: 45.24 – 45.29 Mb	Chr 2: 92.92 – 92.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include vesicular traffic, exocytosis, and secretion.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000019505 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027220 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukuda M, Mikoshiba K (March 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". The Biochemical Journal. 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC 1221650. PMID 11171101.
6. "Entrez Gene: SYT13 synaptotagmin XIII".

Further reading

• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• Overview of all the structural information available in the PDB for UniProt: Q7L8C5 (Human Synaptotagmin-13 (SYT13)) at the PDBe-KB.