SYT11

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.[5][6]

SYT11
Identifiers
Aliases	SYT11, SYT12, sytXI, synaptotagmin 11
External IDs	OMIM: 608741 MGI: 1859547 HomoloGene: 23120 GeneCards: SYT11
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 155,859,567 bp[1] End 155,885,199 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.96 cM Start 88,744,700 bp[2] End 88,775,164 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • clathrin binding • calcium ion binding • syntaxin binding • GO:0001948 protein binding • metal ion binding • translation initiation factor binding • ubiquitin protein ligase binding • SNARE binding • protein homodimerization activity • beta-tubulin binding • calcium-dependent phospholipid binding • phosphatidylserine binding Cellular component • integral component of membrane • cell junction • synapse • integral component of plasma membrane • synaptic vesicle membrane • membrane • cytoplasmic vesicle • vesicle • phagocytic cup • presynaptic active zone membrane • inhibitory synapse • synaptic vesicle • presynapse • dendritic spine • lysosome • cytoplasm • recycling endosome • GO:0097483, GO:0097481 postsynaptic density • cell membrane • cell body • axon • early phagosome • excitatory synapse • neuron projection • terminal bouton • phagocytic vesicle • perinuclear region of cytoplasm • integral component of synaptic vesicle membrane • Schaffer collateral - CA1 synapse • postsynapse • integral component of presynaptic active zone membrane • exocytic vesicle Biological process • negative regulation of neurotransmitter secretion • regulation of phagosome maturation • negative regulation of interleukin-6 secretion • regulation of defense response to bacterium • negative regulation of tumor necrosis factor secretion • calcium ion-regulated exocytosis of neurotransmitter • negative regulation of synaptic vesicle endocytosis • negative regulation of membrane invagination • vesicle fusion • protein homotetramerization • negative regulation of clathrin-dependent endocytosis • negative regulation of phagocytosis • positive regulation of protein localization to phagocytic vesicle • plasma membrane repair • response to wounding • negative regulation of clathrin-coated pit assembly • calcium ion regulated lysosome exocytosis • regulation of calcium ion-dependent exocytosis • regulation of dopamine secretion • vesicle-mediated transport • calcium ion regulated exocytosis • cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23208	229521
Ensembl	ENSG00000132718	ENSMUSG00000068923
UniProt	Q9BT88	Q9R0N3
RefSeq (mRNA)	NM_152280	NM_018804
RefSeq (protein)	NP_689493	NP_061274
Location (UCSC)	Chr 1: 155.86 – 155.89 Mb	Chr 3: 88.74 – 88.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SYT11 has been shown to interact with Parkin (ligase).[7]

References

1. GRCh38: Ensembl release 89: ENSG00000132718 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068923 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
6. "Entrez Gene: SYT11 synaptotagmin XI".
7. Huynh DP, Scoles DR, Nguyen D, Pulst SM (October 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Human Molecular Genetics. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Huynh DP, Scoles DR, Nguyen D, Pulst SM (October 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Human Molecular Genetics. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.
• Glass AS, Huynh DP, Franck T, Woitalla D, Müller T, Pulst SM, Berg D, Krüger R, Riess O (2004). "Screening for mutations in synaptotagmin XI in Parkinson's disease". Journal of Neural Transmission. Supplementum (68): 21–8. PMID 15354386.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Inoue S, Imamura A, Okazaki Y, Yokota H, Arai M, Hayashi N, Furukawa A, Itokawa M, Oishi M (April 2007). "Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia". American Journal of Medical Genetics Part B. 144B (3): 332–40. doi:10.1002/ajmg.b.30465. PMID 17192956.