CDH16

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[5][6][7]

CDH16
Identifiers
Aliases	CDH16, cadherin 16
External IDs	OMIM: 603118 MGI: 106671 HomoloGene: 2997 GeneCards: CDH16
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 66,908,122 bp[1] End 66,918,917 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 104,601,911 bp[2] End 104,624,396 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • integral component of membrane • cell membrane • extracellular exosome • membrane • integral component of plasma membrane • basolateral plasma membrane Biological process • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell signaling • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1014	12556
Ensembl	ENSG00000166589	ENSMUSG00000031881
UniProt	O75309	O88338
RefSeq (mRNA)	NM_001204744 NM_001204745 NM_001204746 NM_004062	NM_001252627 NM_001252628 NM_007663
RefSeq (protein)	NP_001191673 NP_001191674 NP_001191675 NP_004053	NP_001239556 NP_001239557 NP_031689
Location (UCSC)	Chr 16: 66.91 – 66.92 Mb	Chr 8: 104.6 – 104.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000166589 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS (Oct 1998). "cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin". Genomics. 51 (3): 445–51. doi:10.1006/geno.1998.5402. PMID 9721215.
6. Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID 7615566.
7. "Entrez Gene: CDH16 cadherin 16, KSP-cadherin".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney". Am. J. Physiol. 277 (1 Pt 2): F146–56. doi:10.1152/ajprenal.1999.277.1.F146. PMID 10409308.
• Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 253–4. doi:10.1159/000015531. PMID 10828602.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD". Am. J. Physiol. Renal Physiol. 285 (5): F870–80. doi:10.1152/ajprenal.00153.2003. PMID 12851251.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hishikawa K, Marumo T, Miura S, et al. (2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16". Biochem. Biophys. Res. Commun. 328 (1): 288–91. doi:10.1016/j.bbrc.2004.12.167. PMID 15670782.
• Thedieck C, Kuczyk M, Klingel K, et al. (2005). "Expression of Ksp-cadherin during kidney development and in renal cell carcinoma". Br. J. Cancer. 92 (11): 2010–7. doi:10.1038/sj.bjc.6602597. PMC 2361784. PMID 15886705.
• Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications". Am. J. Surg. Pathol. 31 (10): 1528–33. doi:10.1097/PAS.0b013e318058818c. PMID 17895753.

External links

• CDH16 human gene location in the UCSC Genome Browser.
• CDH16 human gene details in the UCSC Genome Browser.