CDH10

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.[5][6]

CDH10
Identifiers
Aliases	CDH10, cadherin 10
External IDs	OMIM: 604555 MGI: 107436 HomoloGene: 68530 GeneCards: CDH10
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p14.2-p14.1 Start 24,487,100 bp[1] End 24,644,978 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A2|15 8.2 cM Start 18,818,947 bp[2] End 19,014,236 bp[2]
Gene ontology Molecular function • calcium ion binding • metal ion binding • cytoskeletal protein binding • protein homodimerization activity • cadherin binding Cellular component • integral component of membrane • cell membrane • membrane • glutamatergic synapse • GABA-ergic synapse • integral component of presynaptic active zone membrane • integral component of postsynaptic specialization membrane • cell surface • catenin complex Biological process • cell adhesion • adherens junction organization • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell adhesion • cell-cell junction assembly • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • cell-cell adhesion mediated by cadherin • cell morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1008	320873
Ensembl	ENSG00000040731	ENSMUSG00000022321
UniProt	Q9Y6N8	P70408
RefSeq (mRNA)	NM_001190450 NM_006727 NM_001317222 NM_001317224 NM_001362460	NM_009865 NM_001316758
RefSeq (protein)	NP_001304151 NP_001304153 NP_006718 NP_001349389 NP_001304153.1	NP_001303687 NP_033995
Location (UCSC)	Chr 5: 24.49 – 24.64 Mb	Chr 15: 18.82 – 19.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

An association with autism has been suggested.[7]

See also

• Cadherin
• Heritability of autism

References

1. GRCh38: Ensembl release 89: ENSG00000040731 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022321 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: cadherin 10".
6. Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
7. Wang K, Zhang H, Ma D, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

External links

• Human CDH10 genome location and CDH10 gene details page in the UCSC Genome Browser.

Further reading

• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Wang K, Zhang H, Ma D, et al. (2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.
• Potkin SG, Guffanti G, Lakatos A, et al. (2009). "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease". PLoS ONE. 4 (8): e6501. doi:10.1371/journal.pone.0006501. PMC 2719581. PMID 19668339.
• Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex". J. Comp. Neurol. 453 (4): 372–88. doi:10.1002/cne.10424. PMID 12389209.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999). "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14". FEBS Lett. 452 (3): 328–34. doi:10.1016/S0014-5793(99)00672-9. PMID 10386616.
• Hillier LD, Lennon G, Becker M, et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219.
• Ma D, Salyakina D, Jaworski JM, et al. (2009). "A genome-wide association study of autism reveals a common novel risk locus at 5p14.1". Ann. Hum. Genet. 73 (Pt 3): 263–73. doi:10.1111/j.1469-1809.2009.00523.x. PMC 2918410. PMID 19456320.
• Hülsken J, Birchmeier W, Behrens J (1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". J. Cell Biol. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.