CALML5

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.[5][6]

CALML5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCALML5, CLSP, calmodulin like 5
External IDsOMIM: 605183 MGI: 1931464 HomoloGene: 49485 GeneCards: CALML5
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p15.1Start5,498,697 bp[1]
End5,499,570 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51806

80796

Ensembl

ENSG00000178372

ENSMUSG00000033765

UniProt

Q9NZT1

Q9JM83

RefSeq (mRNA)

NM_017422

NM_020036

RefSeq (protein)

NP_059118

NP_064420

Location (UCSC)Chr 10: 5.5 – 5.5 MbChr 13: 3.84 – 3.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000178372 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033765 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582.
  6. "Entrez Gene: CALML5 calmodulin-like 5".

Further reading


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