SYT9

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.[5][6]

SYT9
Identifiers
Aliases	SYT9, synaptotagmin 9
External IDs	OMIM: 613528 MGI: 1926373 HomoloGene: 11062 GeneCards: SYT9
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 7,238,778 bp[1] End 7,469,043 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 107,370,728 bp[2] End 107,548,656 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent phospholipid binding • metal ion binding • clathrin binding • calcium ion binding • syntaxin binding • identical protein binding • phosphatidylserine binding • phosphatidylinositol-4,5-bisphosphate binding • SNARE binding Cellular component • cytoplasmic vesicle • integral component of membrane • cell junction • synapse • dense core granule • synaptic vesicle membrane • secretory granule membrane • membrane • secretory granule • cell membrane • clathrin-coated vesicle membrane • integral component of synaptic vesicle membrane • hippocampal mossy fiber to CA3 synapse • exocytic vesicle Biological process • regulation of insulin secretion • positive regulation of calcium ion-dependent exocytosis • regulation of calcium ion-dependent exocytosis • vesicle fusion • calcium ion-regulated exocytosis of neurotransmitter • membrane organization • calcium-dependent activation of synaptic vesicle fusion • regulation of dopamine secretion • synaptic vesicle exocytosis • vesicle-mediated transport • calcium ion regulated exocytosis • cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143425	60510
Ensembl	ENSG00000170743	ENSMUSG00000062542
UniProt	Q86SS6	Q9R0N9
RefSeq (mRNA)	NM_175733	NM_021889
RefSeq (protein)	NP_783860	NP_068689
Location (UCSC)	Chr 11: 7.24 – 7.47 Mb	Chr 7: 107.37 – 107.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SYT9 has been shown to interact with SYNCRIP,[7] TUBB[8] and TRPV1.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000170743 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062542 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
6. "Entrez Gene: SYT9 synaptotagmin IX".
7. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
8. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
9. Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
• Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.

• Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043.
• Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.