GUCA1B

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.[5][6] Alternative names:[7]

• Guanylate cyclase activator 1B
• Retinal guanylyl cyclase activator protein p24

GUCA1B
Identifiers
Aliases	GUCA1B, GCAP2, GUCA2, RP48, guanylate cyclase activator 1B, GCAP 2
External IDs	OMIM: 602275 MGI: 1194489 HomoloGene: 1586 GeneCards: GUCA1B
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 42,183,284 bp[1] End 42,194,956 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 47,385,393 bp[2] End 47,392,967 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • guanylate cyclase regulator activity • metal ion binding • calcium sensitive guanylate cyclase activator activity Cellular component • photoreceptor inner segment • membrane • cell membrane • photoreceptor outer segment • photoreceptor disc membrane Biological process • phototransduction • response to stimulus • cell-cell signaling • positive regulation of guanylate cyclase activity • regulation of guanylate cyclase activity • receptor guanylyl cyclase signaling pathway • body fluid secretion • visual perception • regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2979	107477
Ensembl	ENSG00000112599	ENSMUSG00000023979
UniProt	Q9UMX6	Q8VBV8
RefSeq (mRNA)	NM_002098	NM_146079
RefSeq (protein)	NP_002089	NP_666191
Location (UCSC)	Chr 6: 42.18 – 42.19 Mb	Chr 17: 47.39 – 47.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000112599 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023979 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W (Apr 1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi:10.1006/geno.1996.4513. PMID 9119368.
6. "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".
7. "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.

Further reading

• Wiegand RC, Kato J, Huang MD, et al. (1992). "Human guanylin: cDNA isolation, structure, and activity". FEBS Lett. 311 (2): 150–4. doi:10.1016/0014-5793(92)81387-2. PMID 1327879.
• de Sauvage FJ, Keshav S, Kuang WJ, et al. (1992). "Precursor structure, expression, and tissue distribution of human guanylin". Proc. Natl. Acad. Sci. U.S.A. 89 (19): 9089–93. doi:10.1073/pnas.89.19.9089. PMC 50070. PMID 1409606.
• Otto-Bruc A, Fariss RN, Haeseleer F, et al. (1997). "Localization of guanylate cyclase-activating protein 2 in mammalian retinas". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4727–32. doi:10.1073/pnas.94.9.4727. PMC 20792. PMID 9114059.
• Laura RP, Hurley JB (1998). "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry. 37 (32): 11264–71. doi:10.1021/bi9809674. PMID 9698373.
• Sokal I, Haeseleer F, Arendt A, et al. (1999). "Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1". Biochemistry. 38 (5): 1387–93. doi:10.1021/bi982512k. PMID 9931003.
• Payne AM, Downes SM, Bessant DA, et al. (1999). "Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies". J. Med. Genet. 36 (9): 691–3. doi:10.1136/jmg.36.9.691 (inactive 2020-05-11). PMC 1734430. PMID 10507726.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Sato M, Nakazawa M, Usui T, et al. (2005). "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies". Graefes Arch. Clin. Exp. Ophthalmol. 243 (3): 235–42. doi:10.1007/s00417-004-1015-7. PMID 15452722.

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview