S100G

S100 calcium-binding protein G (S100G) is a protein that in humans is encoded by the S100G gene.[5][6][7]

See also: Calbindin

S100G
Identifiers
Aliases	S100G, CABP, CABP1, CABP9K, CALB3, S100 calcium binding protein G
External IDs	OMIM: 302020 MGI: 104528 HomoloGene: 36150 GeneCards: S100G
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 16,650,158 bp[1] End 16,654,670 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F4 Start 162,961,992 bp[2] End 162,964,599 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	795	12309
Ensembl	ENSG00000169906	ENSMUSG00000040808
UniProt	P29377	P97816
RefSeq (mRNA)	NM_004057	NM_009789
RefSeq (protein)	NP_004048	NP_033919
Location (UCSC)	Chr X: 16.65 – 16.65 Mb	Chr X: 162.96 – 162.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca²⁺ absorption by buffering Ca²⁺ in the cytoplasm and increase ATP-dependent Ca²⁺ transport in duodenal basolateral membrane vesicles.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000169906 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040808 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Howard A, Legon S, Spurr NK, Walters JR (1992). "Molecular cloning and chromosomal assignment of human calbindin-D9k". Biochem Biophys Res Commun. 185 (2): 663–9. doi:10.1016/0006-291X(92)91676-H. PMID 1610358.
6. Jeung EB, Krisinger J, Dann JL, Leung PC (Sep 1992). "Molecular cloning of the full-length cDNA encoding the human calbindin-D9k". FEBS Lett. 307 (2): 224–8. doi:10.1016/0014-5793(92)80772-9. PMID 1379540.
7. "Entrez Gene: S100G S100 calcium binding protein G".

Further reading

• Balmain N (1991). "Calbindin-D9k. A vitamin-D-dependent, calcium-binding protein in mineralized tissues". Clin. Orthop. Relat. Res. (265): 265–76. PMID 2009668.
• Fleet JC, Hock JM (1995). "Identification of osteocalcin mRNA in nonosteoid tissue of rats and humans by reverse transcription-polymerase chain reaction". J. Bone Miner. Res. 9 (10): 1565–73. doi:10.1002/jbmr.5650091009. PMID 7817802.
• Jeung EB, Leung PC, Krisinger J (1994). "The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation". J. Mol. Biol. 235 (4): 1231–8. doi:10.1006/jmbi.1994.1076. PMID 8308886.
• Barley NF, Prathalingam SR, Zhi P, et al. (1999). "Factors involved in the duodenal expression of the human calbindin-D9k gene". Biochem. J. 341 (3): 491–500. doi:10.1042/0264-6021:3410491. PMC 1220384. PMID 10417310.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang L, Klopot A, Freund JN, et al. (2004). "Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1α". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (5): G943–53. doi:10.1152/ajpgi.00121.2004. PMC 2701355. PMID 15217781.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.