Ribosomal protein s6

Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.[5]

RPS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4D5L, 4UJE, 5FLX, 4UJC, 3J7P, 4KZZ, 4UJD, 4KZY, 4D61, 3J7R, 4KZX
Identifiers
Aliases	RPS6, S6, ribosomal protein S6
External IDs	OMIM: 180460 MGI: 98159 HomoloGene: 85949 GeneCards: RPS6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.1 Start 19,375,715 bp[1] End 19,380,236 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C4 Start 86,854,660 bp[2] End 86,857,412 bp[2]
Gene ontology Molecular function • structural constituent of ribosome • GO:0001948 protein binding • protein kinase binding • RNA binding Cellular component • cell body • cytosol • ribosome • membrane • intracellular • nucleolus • small ribosomal subunit • cytoplasmic ribonucleoprotein granule • cell nucleus • nucleoplasm • cytoplasm • polysome • cytosolic small ribosomal subunit • dendrite • perinuclear region of cytoplasm • endoplasmic reticulum • ribonucleoprotein Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • TOR signaling • positive regulation of apoptotic process • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • protein biosynthesis • G1 phase • GO:0007067 mitotic cell cycle • placentation • T cell proliferation involved in immune response • rRNA processing • activation-induced cell death of T cells • mitotic cell cycle checkpoint • gastrulation • oogenesis stage • T cell differentiation in thymus • ribosomal small subunit biogenesis • glucose homeostasis • negative regulation of apoptotic process • erythrocyte development • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6194	20104
Ensembl	ENSG00000137154	ENSMUSG00000028495
UniProt	P62753	P62754
RefSeq (mRNA)	NM_001010	NM_009096
RefSeq (protein)	NP_001001	NP_033122
Location (UCSC)	Chr 9: 19.38 – 19.38 Mb	Chr 4: 86.85 – 86.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ribosomal protein S6
Identifiers
Symbol	RPS6
NCBI gene	6194
HGNC	10429
OMIM	180460
RefSeq	NM_001010
UniProt	P62753
Other data
Locus	Chr. 9 p21

Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate eS6 and that S6K1 and S6K2 predominate this function.

Pathways leading to the induction of human eS6 phosphoryation been found to enhance IL-8 protein synthesis. This mechanism is dependent on A/U-rich proximal sequences (APS) found in the 3'UTR of IL-8 immediately after the stop codon.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137154 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O (September 2005). "Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis". Genes Dev. 19 (18): 2199–2211. doi:10.1101/gad.351605. PMC 1221890. PMID 16166381.
6. Ang Z, Abdi Gunawan Koen R, Er JZ, Lee LT, Tam Kit Chung J, Guo H, Ding JL (2019). "Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation". PLoS Genet. 15 (4): e1008077. doi:10.1371/journal.pgen.1008077. PMC 6476525. PMID 30969964.

External links

• Ribosomal+Protein+S6 at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P62753 (Human 40S ribosomal protein S6) at the PDBe-KB.