mir-632 microRNA precursor family

In molecular biology mir-632 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-632
Identifiers
Symbolmir-632
RfamRF01010
miRBase familyMIPF0000527
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

miR-632 and MDS

miR-632 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). In particular, its levels show high discrimination between MDS and normal controls, and expression is decreased in MDS.[1] In this way it can be used as a potential diagnostic marker for MDS.

DNAJB6 protein

miR-632 targets the coding region of the DNAJB6 protein, a member of the Heat Shock Protein 40 (HSP40) family which shows constitutive expression. DNAJB6 is known to be a negative regulator of tumour progression in breast cancer and its levels are compromised in advanced tumour progression. miR-632 has been linked to be downregulation of DNAJB6 and is capable of silencing both spliced variants of this protein.[2] It is currently unknown whether miR-632 may be just one of many negative regulators controlling DNAJB6 levels.

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See also

References
  1. Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, et al. (2011). "Diagnostic microRNAs in myelodysplastic syndrome". Exp Hematol. 39 (9): 915–926.e2. doi:10.1016/j.exphem.2011.06.002. PMID 21703983.
  2. Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS (2012). "Micro-RNA-632 downregulates DNAJB6 in breast cancer". Lab Invest. 92 (9): 1310–7. doi:10.1038/labinvest.2012.87. PMC 3660857. PMID 22710984.


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