mir-135 microRNA precursor family
The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat.[1][2] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000028). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.
| mir-135 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-135 | |
| Identifiers | |
| Symbol | mir-135 |
| Rfam | RF00246 |
| miRBase | MI0000452 |
| miRBase family | MIPF0000028 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
| PDB structures | PDBe |
Targets of miR-135
- Nagel et al.. showed that miR-135a and b target the 3' untranslated region of the APC gene.[3]
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References
- Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. hdl:11858/00-001M-0000-0010-94EF-7. PMID 12007417.
- Kim, J; Krichevsky A; Grad Y; Hayes GD; Kosik KS; Church GM; Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA. 101 (1): 360–365. Bibcode:2003PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248.
- Nagel R, le Sage C, Diosdado B, et al. (July 2008). "Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer". Cancer Research. 68 (14): 5795–802. doi:10.1158/0008-5472.CAN-08-0951. PMID 18632633.
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