mir-764 microRNA precursor family

In molecular biology mir-764 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-764
Identifiers
Symbolmir-764
RfamRF01920
miRBase familyMIPF0000707
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Osteoblast Differentiation

Expression of the mature miR-764-5p sequence is upregulated during osteoblast differentiation in both skull-specific calvarial and osteoblast progenitor cells. The channel-forming integral protein, CHIP, is regulated by miR-764-5p at its 3'UTR, and there is negative correlation between expression of the two. Increased CHIP levels are observed with inhibition of miR-764-5p, whilst enhanced miR-764-3p expression sees decreased CHIP levels.[1] The differentiation fate of osteoblast progenitor cells is altered by impaired miR-764-3p levels due to CHIP. Osteoblast differentiation from progenitor cells has been shown to be positively regulated by repressed CHIP translation.

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See also

References
  1. Guo J, Ren F, Wang Y, Li S, Gao Z, Wang X, et al. (2012). "miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression". J Bone Miner Res. 27 (7): 1607–18. doi:10.1002/jbmr.1597. PMID 22407479.

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