mir-48

mir-48 microRNA is a microRNA which is found in nematodes, in which it controls developmental timing. It acts in the heterochronic pathway, where it controls the timing of cell fate decisions in the vulva and hypodermis during larval development.[1]

Gene structure and location

Along with mir-241, mir-48 is found in the lin-58 allele between the genes hum-5 and unc-76.[2] It is related to (at least) three other miRNAs (let-7,mir-84 and mir-241), with which it shares eight identical bases at the 5′ end of the mature miRNA.[3]

Function

mir-48, along with let-7, mir-84 and mir-241, controls developmental timing events in C. elegans proliferative seam cells and hypodermal syncytial cells. Double mutations in mir-48 and mir-214 result in worms displaying a retarded cell lineage phenotype; extra seam cells are observed in the L3 and L4 developmental stages when compared to wild-type worms. It is thought that the extra cells arise due to mutant miRNAs being unable to repress the gene hbl-1, which also plays a role in developmental timing.[3]

gollark: Well, you actually have a specific target, so I'll look.
gollark: What?
gollark: It's about as useful as the contents of my "random files" folder, which contains everything from zipped backups of my pastebin to some random textbooks Springer temporarily made free to some papers which looked interesting to HTML file archives of interesting web content.
gollark: There's not even a "README" explaining why any of the stuff in it is there and providing an overview, this *is not readable*.
gollark: If you want anyone to actually evaluate whatever claims you're making, actually explain them rather than just dumping a random trashpile on them.

References
  1. Li, M.; Jones-Rhoades, M. W.; Lau, N. C.; Bartel, D. P.; Rougvie, A. E. (2005). "Regulatory Mutations of mir-48, a C. Elegans let-7 Family MicroRNA, Cause Developmental Timing Defects". Developmental Cell. 9 (3): 415–422. doi:10.1016/j.devcel.2005.08.002. PMID 16139229.
  2. Lau, N. C.; Lim, L. P.; Weinstein, E. G.; Bartel, D. P. (2001). "An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans". Science. 294 (5543): 858–862. doi:10.1126/science.1065062. PMID 11679671.
  3. Abbott, A. L.; Alvarez-Saavedra, E.; Miska, E. A.; Lau, N. C.; Bartel, D. P.; Horvitz, H. R.; Ambros, V. (2005). "The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans". Developmental Cell. 9 (3): 403–414. doi:10.1016/j.devcel.2005.07.009. PMC 3969732. PMID 16139228.

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