mir-612 microRNA precursor family
mir-612 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma.
| mir-612 | |
|---|---|
| Identifiers | |
| Symbol | mir-612 |
| Rfam | RF00959 |
| miRBase family | MIPF0000464 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota |
| PDB structures | PDBe |
miR-612 and p53
The microRNA miR-2185 has a strong inhibitory effect on the tumour suppressor protein p53, acting through targeting its 3'UTR. MiR-612 is of the same seed sequence as miR-2185 but, despite this, is yet to be identified as a p53 inhibitor.[1]
gollark: There are some companies with specialized hardware for ML which might compete with Nvidia.
gollark: The price is probably going to come down. Eventually.
gollark: How affordable*!\* not affordable
gollark: It probably couldn't work at all without that, but still.
gollark: It is kind of a shame that all the cutting-edge AI stuff requires ridiculously powerful hardware now.
See also
References
- Tian S, Huang S, Wu S, Guo W, Li J, He X (2010). "MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region". Biochem Biophys Res Commun. 396 (2): 435–9. doi:10.1016/j.bbrc.2010.04.112. PMID 20417621.
Further reading
- Jian, P.; Li, Z.; Fang, T.; Jian, W.; Zhuan, Z.; Mei, L.; Yan, W.; Jian, N. (2011). "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology. 4: 20. doi:10.1186/1756-8722-4-20. PMC 3094392. PMID 21518431.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.