mir-636 microRNA precursor family
In molecular biology mir-636 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-636 | |
|---|---|
| Identifiers | |
| Symbol | mir-636 |
| Rfam | RF01008 |
| miRBase family | MIPF0000524 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
miR-636 and MDS
miR-636 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). Its levels correspond to high discrimination between MDS and normal controls, and expression is decreased in MDS.[1] In this way it can be used as a potential diagnostic marker for MDS.
Glucocorticoid resistance
Resistance to glucocorticoids (GC) used in the treatment of blood-related malignancies greatly impairs their clinical utility. The active glucocorticoid receptor GR-α is required for an effective response to GCs, but this is significantly downregulated in GC-resistant cell lines MM.1Re and MM.1RL. miR-636 has been found to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. It has therefore been identified as a possible candidate responsible for postranscriptional silencing of GR-α in GC-resistant cells.[2]
See also
References
- Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, et al. (2011). "Diagnostic microRNAs in myelodysplastic syndrome". Exp Hematol. 39 (9): 915–926.e2. doi:10.1016/j.exphem.2011.06.002. PMID 21703983.
- Tessel MA, Benham AL, Krett NL, Rosen ST, Gunaratne PH (2011). "Role for microRNAs in regulating glucocorticoid response and resistance in multiple myeloma". Horm Cancer. 2 (3): 182–9. doi:10.1007/s12672-011-0072-8. PMC 3725966. PMID 21761344.