mir-636 microRNA precursor family

In molecular biology mir-636 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-636
Identifiers
Symbolmir-636
RfamRF01008
miRBase familyMIPF0000524
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

miR-636 and MDS

miR-636 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). Its levels correspond to high discrimination between MDS and normal controls, and expression is decreased in MDS.[1] In this way it can be used as a potential diagnostic marker for MDS.

Glucocorticoid resistance

Resistance to glucocorticoids (GC) used in the treatment of blood-related malignancies greatly impairs their clinical utility. The active glucocorticoid receptor GR-α is required for an effective response to GCs, but this is significantly downregulated in GC-resistant cell lines MM.1Re and MM.1RL. miR-636 has been found to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. It has therefore been identified as a possible candidate responsible for postranscriptional silencing of GR-α in GC-resistant cells.[2]

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See also

References
  1. Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, et al. (2011). "Diagnostic microRNAs in myelodysplastic syndrome". Exp Hematol. 39 (9): 915–926.e2. doi:10.1016/j.exphem.2011.06.002. PMID 21703983.
  2. Tessel MA, Benham AL, Krett NL, Rosen ST, Gunaratne PH (2011). "Role for microRNAs in regulating glucocorticoid response and resistance in multiple myeloma". Horm Cancer. 2 (3): 182–9. doi:10.1007/s12672-011-0072-8. PMC 3725966. PMID 21761344.


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