mir-939 microRNA precursor family

In molecular biology mir-939 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-939
Identifiers
Symbolmir-939
RfamRF00981
miRBase familyMIPF0000490
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Human inducible Nitric Oxide Synthase

miR-939 directly regulates and translationally blocks the gene expression of human inducible nitric oxide synthase (hiNOS) by binding to its 3'UTR. There is dual regulation of hiNOS gene expression, with cytokines inducing hiNOS transcription whilst also increasing miR-939 levels.[1] Two functional binding sites within the hiNOS 3'UTR are essential for miR-939-mediated translational blockade and miR-939 has been shown to decrease cytokine-induced hiNOS expression, despite hiNOS mRNA levels and stability remaining unaffected. It has further been found that endogenous miR-939 expression in the liver may be induced by cytokines.

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See also

References
  1. Guo Z, Shao L, Zheng L, Du Q, Li P, John B, et al. (2012). "miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes". Proc Natl Acad Sci U S A. 109 (15): 5826–31. doi:10.1073/pnas.1118118109. PMC 3326458. PMID 22451906.

Further reading
  1. Semaan, N.; Frenzel, L.; Alsaleh, G.; Suffert, G.; Gottenberg, J. E.; Sibilia, J.; Pfeffer, S.; Wachsmann, D. (2011). El Khoury, Joseph (ed.). "MiR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization". PLoS ONE. 6 (5): e19827. doi:10.1371/journal.pone.0019827. PMC 3096642. PMID 21611196.
  2. Nymark, P.; Guled, M.; Borze, I.; Faisal, A.; Lahti, L.; Salmenkivi, K.; Kettunen, E.; Anttila, S.; Knuutila, S. (2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer" (PDF). Genes, Chromosomes and Cancer. 50 (8): 585–597. doi:10.1002/gcc.20880. PMID 21563230.

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