miR-144

miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.

miR-144
Conserved secondary structure of miR-144 precursor microRNA
Identifiers
SymbolmiR-144
Alt. SymbolsMIR144
RfamRF00682
miRBaseMI0000460
miRBase familyMIPF0000093
NCBI Gene406936
HGNC31531
OMIM612070
RefSeqNR_029685
Other data
RNA typemiRNA
Domain(s)Mammalia
GO0035195
SO0001244
LocusChr. 17 q11.2
PDB structuresPDBe

GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]

Function

miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]

Applications

miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]

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References
  1. Ambros V (Dec 2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  2. Wang W, Peng B, Wang D, Ma X, Jiang D, Zhao J, Yu L (Oct 2011). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets". International Journal of Cancer. 129 (7): 1624–34. doi:10.1002/ijc.25818. PMID 21128228.
  3. Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG, Fan GC (Nov 2010). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death". Journal of Molecular and Cellular Cardiology. 49 (5): 841–50. doi:10.1016/j.yjmcc.2010.08.007. PMC 2949485. PMID 20708014.
  4. Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ, O'Carroll D (Jul 2010). "The miR-144/451 locus is required for erythroid homeostasis". The Journal of Experimental Medicine. 207 (7): 1351–8. doi:10.1084/jem.20100458. PMC 2901075. PMID 20513743.
  5. Karolina DS, Armugam A, Tavintharan S, Wong MT, Lim SC, Sum CF, Jeyaseelan K (2011). "MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus". PLOS ONE. 6 (8): e22839. doi:10.1371/journal.pone.0022839. PMC 3148231. PMID 21829658.
  6. Dinan TG (Apr 2010). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field". The International Journal of Neuropsychopharmacology. 13 (3): 395–404. doi:10.1017/S1461145709990800. PMID 19849891.(subscription required)

Further reading
  • Zhang HY, Zheng SJ, Zhao JH, Zhao W, Zheng LF, Zhao D, Li JM, Zhang XF, Chen ZB, Yi XN (Apr 2011). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection". Brain Research. 1383: 62–70. doi:10.1016/j.brainres.2011.01.067. PMID 21276775.

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