mir-872 microRNA precursor family

In molecular biology mir-872 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-872
Identifiers
Symbolmir-872
RfamRF00918
miRBase familyMIPF0000399
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Sertoli Cell Expression

miR-872 has been found to be expressed in sertoli cells and to post-transcriptionally target the Sod-1 gene, which encodes the copper/zinc-binding superoxide dismutase 1 (SOD-1) enzyme.[1] Overproduction of SOD-1 increases oxidative damage and through this results in enhanced apoptosis and cell death.

Insulin-regulated HO-1 expression

Insulin infusion in rats has seen increased levels of heme-oxygenase 1 expression, blocked by inhibited activation of PI3K or protein kinase C. miR-872 levels are reduced with inhibition of adipocytes of the 3T3-L1 cell line, along with those of miRNAs-155 and -183. Insulin is therefore able to increase expression of HO-1 through miR-872 downregulation, as well as via pathways dependent upon PI3K and protein kinase C.[2]

gollark: Or, well, with a user API somewhat like how modems work even though the implementation details are totally different.
gollark: Skynet basically just lets you send messages via mine in a similar way to how modems work.
gollark: Without *someone*'s webserver, you *cannot* do cross-server communication in CC.
gollark: But it would probably be easier authentication-wise to have a dedicated HTTP/websocket server of some sort.
gollark: Skynet is the public version.

See also

References
  1. Papaioannou MD, Lagarrigue M, Vejnar CE, Rolland AD, Kühne F, Aubry F, et al. (2011). "Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice". Mol Cell Proteomics. 10 (4): M900587MCP200. doi:10.1074/mcp.M900587-MCP200. PMC 3069350. PMID 20467044.
  2. Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC (2011). "Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation". Endocrinology. 152 (2): 384–93. doi:10.1210/en.2010-0493. PMID 21147878.

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