CCL7

CCL7
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1BO0, 1NCV, 4ZKC
Identifiers
Aliases	CCL7, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7, C-C motif chemokine ligand 7
External IDs	OMIM: 158106 HomoloGene: 4568 GeneCards: CCL7
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	34,272,242 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cytokine activity; • heparin binding; • chemokine activity; • CCR1 chemokine receptor binding; • GO:0001948 protein binding; • CCR2 chemokine receptor binding; • CCR chemokine receptor binding;
Cellular component	• cell; • extracellular region; • extracellular;
Biological process	• G-protein coupled receptor signaling pathway; • monocyte chemotaxis; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • cell-cell signaling; • eosinophil chemotaxis; • cellular calcium ion homeostasis; • neutrophil chemotaxis; • chemotaxis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cytoskeleton organization; • cellular response to interleukin-1; • immune response; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • cellular response to interferon-gamma; • inflammatory response; • signal transduction; • response to gamma radiation; • cellular response to ethanol; • regulation of receptor activity; • lymphocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6354
	n/a
	ENSG00000108688
	n/a
	P80098
	n/a
	NM_006273
	n/a
	NP_006264
	n/a
	Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-chemotactic protein 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function . It is produced by certain tumor cell lines and by macrophages.[3] This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines[4] and is most closely related to CCL2 (previously called MCP1).

Interactions

CCL7 has been shown to interact with MMP2.[5] It binds to the CCR2 receptor.

gollark: Well, you could understand it if you learned about it, I expect.

gollark: μ is the mean (average, ish) of a random variable. σ, as I said, is standard deviation, which is sort of like the average distance of samples from that random variable from the mean μ.

gollark: Not really.

gollark: I don't think you understood this correctly.

gollark: That is not specific to physics. The numbers are the probability of a random sample lying within that region. The μ and μ+σ and such are saying mean + n standard deviations.

References

GRCh38: Ensembl release 89: ENSG00000108688 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011.
Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328.
McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science. UNITED STATES. 289 (5482): 1202–6. Bibcode:2000Sci...289.1202M. doi:10.1126/science.289.5482.1202. ISSN 0036-8075. PMID 10947989.

Menten P, Wuyts A, Van Damme J (2002). "Monocyte chemotactic protein-3". Eur. Cytokine Netw. 12 (4): 554–60. PMID 11781181.
Van Damme J, Proost P, Lenaerts JP, Opdenakker G (1992). "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family". J. Exp. Med. 176 (1): 59–65. doi:10.1084/jem.176.1.59. PMC 2119277. PMID 1613466.
Ben-Baruch A, Xu L, Young PR, et al. (1995). "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3". J. Biol. Chem. 270 (38): 22123–8. doi:10.1074/jbc.270.38.22123. PMID 7545673.
Opdenakker G, Fiten P, Nys G, et al. (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328.
Minty A, Chalon P, Guillemot JC, et al. (1993). "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression". Eur. Cytokine Netw. 4 (2): 99–110. PMID 8318676.
Opdenakker G, Froyen G, Fiten P, et al. (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011.
Combadiere C, Ahuja SK, Van Damme J, et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B". J. Biol. Chem. 270 (50): 29671–5. doi:10.1074/jbc.270.50.29671. PMID 8530354.
Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". Cytokine. 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.
Daugherty BL, Siciliano SJ, DeMartino JA, et al. (1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD (1996). "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3". FEBS Lett. 395 (2–3): 277–82. doi:10.1016/0014-5793(96)01024-1. PMID 8898111.
Meunier S, Bernassau JM, Guillemot JC, et al. (1997). "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy". Biochemistry. 36 (15): 4412–22. doi:10.1021/bi9627929. PMID 9109648.
Polentarutti N, Introna M, Sozzani S, et al. (1997). "Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells". Eur. Cytokine Netw. 8 (3): 271–4. PMID 9346360.
Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
Nibbs RJ, Wylie SM, Yang J, et al. (1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J. Biol. Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
Wang JM, Ueda H, Howard OM, et al. (1998). "HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation". J. Immunol. 161 (8): 4309–17. PMID 9780207.
Albini A, Ferrini S, Benelli R, et al. (1998). "HIV-1 Tat protein mimicry of chemokines". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13153–8. Bibcode:1998PNAS...9513153A. doi:10.1073/pnas.95.22.13153. PMC 23742. PMID 9789057.
Rabin RL, Park MK, Liao F, et al. (1999). "Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling". J. Immunol. 162 (7): 3840–50. PMID 10201901.
Wedemeyer J, Lorentz A, Göke M, et al. (1999). "Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa". Gut. 44 (5): 629–35. doi:10.1136/gut.44.5.629. PMC 1727483. PMID 10205198.
Blanpain C, Migeotte I, Lee B, et al. (1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist". Blood. 94 (6): 1899–905. PMID 10477718.
Jordan NJ, Kolios G, Abbot SE, et al. (1999). "Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells". J. Clin. Invest. 104 (8): 1061–9. doi:10.1172/JCI6685. PMC 408573. PMID 10525044.

External links

Human CCL7 genome location and CCL7 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108688 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8461011-3] Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J (1993). "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines". Biochem. Biophys. Res. Commun. 191 (2): 535–42. doi:10.1006/bbrc.1993.1251. PMID 8461011.

[pmid7916328-4] Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J (1994). "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12". Genomics. 21 (2): 403–8. doi:10.1006/geno.1994.1283. PMID 7916328.

[pmid10947989-5] McQuibban, G A; Gong J H; Tam E M; McCulloch C A; Clark-Lewis I; Overall C M (August 2000). "Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3". Science. UNITED STATES. 289 (5482): 1202–6. Bibcode:2000Sci...289.1202M. doi:10.1126/science.289.5482.1202. ISSN 0036-8075. PMID 10947989.

CCL7

Interactions

References

Further reading

External links