CCL1
Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines.[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
| chemokine (C-C motif) ligand 1 | |
|---|---|
| Identifiers | |
| Symbol | CCL1 |
| Alt. symbols | SCYA1, I-309, TCA3, P500, SISe |
| NCBI gene | 6346 |
| HGNC | 10609 |
| OMIM | 182281 |
| PDB | 1EL0 |
| RefSeq | NM_002981 |
| UniProt | P22362 |
| Other data | |
| Locus | Chr. 17 q11.2 |
References
- Miller MD, Krangel MS (April 1992). "The human cytokine I-309 is a monocyte chemoattractant". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2950–4. doi:10.1073/pnas.89.7.2950. PMC 48781. PMID 1557400.
- Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
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