CCL24

Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.[1] This gene is located on human chromosome 7.[2]

chemokine (C-C motif) ligand 24
Identifiers
SymbolCCL24
Alt. symbolsSCYA24, Ckb-6, MPIF-2, eotaxin-2
NCBI gene6369
HGNC10623
OMIM602495
PDB1EIG
RefSeqNM_002991
UniProtO00175
Other data
LocusChr. 7 q11.23

Function

CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.[1]

Clinical significance

Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[4]

gollark: Apparently I also have half the usual upload speed for some horrible reason, so that might be causing it.
gollark: ``` 7: peer7-et-0-1-7.telehouse.ukcore.bt.net 67.970ms 8: 195.99.126.233 26.381ms asymm 7 9: 141.101.71.47 26.857ms asymm 8 10: 172.70.88.137 25.512ms asymm 9 11: 172.70.88.27 31.208ms asymm 10 12: 141.101.106.35 43.680ms asymm 11 13: 141.101.70.144 61.650ms pmtu 1476```I have no idea how to interpret this.
gollark: Usually it's my extremely janky WiFi network failing, but it seems to be working fine today. I'll tracepathize it.
gollark: It might be that, or my internet connection. I can't really tell.
gollark: I can't actually do anything except move around slightly. I would have assumed it was a network issue, but htop says I'm only doing a few tens of KB/s.

References
  1. Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997). "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. doi:10.1084/jem.185.7.1163. PMC 2196270. PMID 9104803.
  2. Hillier LW, Fulton RS, Fulton LA, et al. (July 2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  3. White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997). "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. PMID 9365122.
  4. Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009). "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy. 65 (3): 338–346. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.



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