CXCL7

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.[3]

PPBP
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesPPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDsOMIM: 121010 HomoloGene: 136759 GeneCards: PPBP
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q13.3Start73,986,439 bp[1]
End73,988,190 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5473

n/a

Ensembl

ENSG00000163736

n/a

UniProt

P02775

n/a

RefSeq (mRNA)

NM_002704

n/a

RefSeq (protein)

NP_002695

n/a

Location (UCSC)Chr 4: 73.99 – 73.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[4]

It is a protein that is released in large amounts from platelets following their activation.[5] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163736 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)".
  4. Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
  5. Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785–9. PMID 1826003.
  6. Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368.
  7. Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.

Further reading

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