C-c motif chemokine ligand 27

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [5]

CCL27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUM
Identifiers
Aliases	CCL27, ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27, C-C motif chemokine ligand 27
External IDs	OMIM: 604833 MGI: 1891389 HomoloGene: 104838 GeneCards: CCL27
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,661,880 bp[1] End 34,664,048 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 Start 42,655,251 bp[2] End 42,656,005 bp[2]
Gene ontology Molecular function • chemokine activity • cytokine activity • CCR3 chemokine receptor binding • GO:0001948 protein binding Cellular component • extracellular region • extracellular Biological process • chemotaxis • cell-cell signaling • immune response • cell chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of receptor activity • G-protein coupled receptor signaling pathway • positive regulation of T cell chemotaxis • positive regulation of mononuclear cell migration • positive regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10850	100040048
Ensembl	ENSG00000213927	ENSMUSG00000096826
UniProt	Q9Y4X3	Q9Z1X0
RefSeq (mRNA)	NM_006664	NM_001199959 NM_001199960 NM_001199961
RefSeq (protein)	NP_006655	NP_001157518 NP_001186891 NP_001186892 NP_001371185 NP_001371186 NP_001371187 NP_001041644 NP_001157516 NP_001157517 NP_001333994 NP_001348175 NP_035466 NP_001186894 NP_001186895 NP_001254631 NP_001254632 NP_001254633 NP_001186888 NP_001186889 NP_001186890 NP_001371188 NP_001371189
Location (UCSC)	Chr 9: 34.66 – 34.66 Mb	Chr 4: 42.66 – 42.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

chemokine (C-C motif) ligand 27
Identifiers
Symbol	CCL27
Alt. symbols	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gene	10850
HGNC	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Other data
Locus	Chr. 9 q13

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[8] The gene for CCL27 is located on human chromosome 9.[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

References

1. GRCh38: Ensembl release 89: ENSG00000213927 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000096826 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: C-C motif chemokine ligand 27". Retrieved 2018-03-23.
6. Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
7. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.
8. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
9. Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. doi:10.1016/s0014-5793(99)01406-4. PMID 10556532.

Further reading

• Mackay CR (February 2002). "New avenues for anti-inflammatory therapy". Nature Medicine. 8 (2): 117–8. doi:10.1038/nm0202-117. PMID 11821893.
• Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (March 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology. 111 (3): 592–7. doi:10.1067/mai.2003.114. PMID 12642842.
• Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E (February 2004). "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". The Journal of Allergy and Clinical Immunology. 113 (2): 334–40. doi:10.1016/j.jaci.2003.12.007. PMID 14767451.
• Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (September 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Experimental Dermatology. 13 (9): 551–7. doi:10.1111/j.0906-6705.2004.00202.x. PMID 15335355.
• Hirata T, Furukawa Y, Yang BG, Hieshima K, Fukuda M, Kannagi R, et al. (December 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". The Journal of Biological Chemistry. 279 (50): 51775–82. doi:10.1074/jbc.M409868200. PMID 15466853.
• Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (January 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine. 29 (2): 49–55. doi:10.1016/j.cyto.2004.09.008. PMID 15598438.
• Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology. 14 (2): 109–16. doi:10.1111/j.0906-6705.2005.00226.x. PMID 15679580.
• Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (February 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology. 15 (2): 95–100. doi:10.1111/j.1600-0625.2005.00390.x. PMID 16433680.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.