IFNK

Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[5][6][7]

IFNK
Identifiers
Aliases	IFNK, IFNT1, INFE1, interferon kappa
External IDs	OMIM: 615326 MGI: 2683287 HomoloGene: 36384 GeneCards: IFNK
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 27,524,314 bp[1] End 27,526,498 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 35,152,056 bp[2] End 35,154,005 bp[2]
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding • cytokine receptor binding Cellular component • extracellular region • extracellular Biological process • natural killer cell activation involved in immune response • B cell differentiation • defense response • response to virus • natural killer cell activation • B cell proliferation • regulation of transcription, DNA-templated • humoral immune response • adaptive immune response • positive regulation of peptidyl-serine phosphorylation of STAT protein • defense response to virus • response to exogenous dsRNA • negative regulation of cell proliferation • cytokine-mediated signaling pathway • positive regulation of innate immune response • T cell activation involved in immune response • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56832	387510
Ensembl	ENSG00000147896	ENSMUSG00000042993
UniProt	Q9P0W0	Q7TSL0
RefSeq (mRNA)	NM_020124	NM_199157
RefSeq (protein)	NP_064509	NP_954608
Location (UCSC)	Chr 9: 27.52 – 27.53 Mb	Chr 4: 35.15 – 35.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000147896 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042993 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: interferon".
6. LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA (October 2001). "Interferon-kappa, a novel type I interferon expressed in human keratinocytes". J. Biol. Chem. 276 (43): 39765–71. doi:10.1074/jbc.M102502200. PMID 11514542.
7. Nardelli B, Zaritskaya L, Semenuk M, Cho YH, LaFleur DW, Shah D, Ullrich S, Girolomoni G, Albanesi C, Moore PA (November 2002). "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system". J. Immunol. 169 (9): 4822–30. doi:10.4049/jimmunol.169.9.4822. PMID 12391192.

3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]

Further reading

• Liu C, Batliwalla F, Li W, et al. (2008). "Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis". Mol. Med. 14 (9–10): 575–81. doi:10.2119/2008-00056.Liu. PMC 2443997. PMID 18615156.
• DeCarlo CA, Severini A, Edler L, et al. (2010). "IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes". Lab. Invest. 90 (10): 1482–91. doi:10.1038/labinvest.2010.95. PMID 20479716.
• Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
• Yang XR, Liang X, Pfeiffer RM, et al. (2010). "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer. 9 (4): 625–33. doi:10.1007/s10689-010-9356-3. PMC 3233727. PMID 20574843.
• Ferreira RC, Pan-Hammarström Q, Graham RR, et al. (2010). "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency". Nat. Genet. 42 (9): 777–80. doi:10.1038/ng.644. PMID 20694011.
• Laaksovirta H, Peuralinna T, Schymick JC, et al. (2010). "Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study". Lancet Neurol. 9 (10): 978–85. doi:10.1016/S1474-4422(10)70184-8. PMC 2965392. PMID 20801718.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Rincon-Orozco B, Halec G, Rosenberger S, et al. (2009). "Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells". Cancer Res. 69 (22): 8718–25. doi:10.1158/0008-5472.CAN-09-0550. PMID 19887612.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• van Es MA, Veldink JH, Saris CG, et al. (2009). "Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis". Nat. Genet. 41 (10): 1083–7. doi:10.1038/ng.442. PMID 19734901.
• Harley IT, Niewold TB, Stormont RM, et al. (2010). "The role of genetic variation near interferon-kappa in systemic lupus erythematosus". J. Biomed. Biotechnol. 2010: 1–11. doi:10.1155/2010/706825. PMC 2914299. PMID 20706608.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.