Auxilin

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[5][6][7]

DNAJC6
Identifiers
AliasesDNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDsOMIM: 608375 MGI: 1919935 HomoloGene: 8865 GeneCards: DNAJC6
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.3Start65,248,219 bp[1]
End65,415,871 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9829

72685

Ensembl

ENSG00000116675

ENSMUSG00000028528

UniProt

O75061

Q80TZ3

RefSeq (mRNA)

NM_001256864
NM_001256865
NM_014787

RefSeq (protein)

NP_001243793
NP_001243794
NP_055602

Location (UCSC)Chr 1: 65.25 – 65.42 MbChr 4: 101.5 – 101.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[7]

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[8] The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000116675 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028528 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  6. Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. PMC 312896. PMID 11147971.
  7. "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
  8. Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.
  9. "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.
  10. Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531.

Further reading

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