TPM4

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.[3][4]

TPM4
Identifiers
Aliases	TPM4, HEL-S-108, tropomyosin 4
External IDs	OMIM: 600317 HomoloGene: 100849 GeneCards: TPM4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12-p13.11 Start 16,067,021 bp[1] End 16,103,002 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • actin binding • structural constituent of muscle • GO:0001948 protein binding • metal ion binding • identical protein binding • protein homodimerization activity • protein heterodimerization activity • actin filament binding Cellular component • cytoplasm • filamentous actin • podosome • cytosol • muscle thin filament tropomyosin • cortical cytoskeleton • extracellular exosome • cytoskeleton • membrane • stress fiber • focal adhesion • actin filament • actin cytoskeleton Biological process • movement of cell or subcellular component • osteoblast differentiation • muscle filament sliding • muscle contraction • actin filament organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7171	n/a
Ensembl	ENSG00000167460	n/a
UniProt	P67936	n/a
RefSeq (mRNA)	NM_001145160 NM_003290 NM_001367836 NM_001367837 NM_001367838	n/a
RefSeq (protein)	NP_001138632 NP_003281 NP_001354765 NP_001354766 NP_001354767	n/a
Location (UCSC)	Chr 19: 16.07 – 16.1 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000167460 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Wilton SD, Lim L, Dorosz SD, Gunn HC, Eyre HJ, Callen DF, Laing NG (Jul 1996). "Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (4): 294–6. doi:10.1159/000134206. PMID 8641132.
4. "Entrez Gene: TPM4 tropomyosin 4".

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
• MacLeod AR, Talbot K, Smillie LB, Houlker C (1987). "Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin". J. Mol. Biol. 194 (1): 1–10. doi:10.1016/0022-2836(87)90710-8. PMID 3612796.
• MacLeod AR, Houlker C, Reinach FC, et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9. doi:10.1073/pnas.82.23.7835. PMC 390864. PMID 3865200.
• Lawrence B, Perez-Atayde A, Hibbard MK, et al. (2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". Am. J. Pathol. 157 (2): 377–84. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
• Meech SJ, McGavran L, Odom LF, et al. (2001). "Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion". Blood. 98 (4): 1209–16. doi:10.1182/blood.V98.4.1209. PMID 11493472.
• Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.