TEKT1

Tektin 1 is a protein that in humans is encoded by the TEKT1 gene.[5][6]

TEKT1
Identifiers
Aliases	TEKT1, tektin 1
External IDs	OMIM: 609002 MGI: 1333819 HomoloGene: 7973 GeneCards: TEKT1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 6,789,133 bp[1] End 6,831,761 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,344,722 bp[2] End 72,362,442 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • microtubule cytoskeleton • cell projection • cilium • microtubule • cytoskeleton • cell nucleus • sperm flagellum • motile cilium Biological process • flagellated sperm motility • cilium morphogenesis • cilium movement involved in cell motility Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83659	21689
Ensembl	ENSG00000167858	ENSMUSG00000020799
UniProt	Q969V4	Q9DAJ2
RefSeq (mRNA)	NM_053285	NM_001282006 NM_001282007 NM_011569
RefSeq (protein)	NP_444515	NP_001268935 NP_001268936 NP_035699
Location (UCSC)	Chr 17: 6.79 – 6.83 Mb	Chr 11: 72.34 – 72.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000167858 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020799 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: tektin 1".
6. Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rose JE, Behm FM, Drgon T, et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Newby PR, Pickles OJ, Mazumdar S, et al. (2010). "Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study". Eur. J. Hum. Genet. 18 (9): 1021–6. doi:10.1038/ejhg.2010.55. PMC 2987410. PMID 20442750.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Iguchi N, Tanaka H, Nakamura Y, et al. (2002). "Cloning and characterization of the human tektin-t gene". Mol. Hum. Reprod. 8 (6): 525–30. doi:10.1093/molehr/8.6.525. PMID 12029069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.