Tropomodulin 3

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.[7][8]

TMOD3
Identifiers
Aliases	TMOD3, UTMOD, tropomodulin 3
External IDs	OMIM: 605112 MGI: 1355315 HomoloGene: 8727 GeneCards: TMOD3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,829,628 bp[1] End 51,947,295 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.3 cM Start 75,497,707 bp[2] End 75,559,657 bp[2]
Gene ontology Molecular function • actin binding • cadherin binding involved in cell-cell adhesion • tropomyosin binding Cellular component • cytoplasm • cytoskeleton • striated muscle thin filament • myofibril Biological process • pointed-end actin filament capping • positive regulation of mitotic cell cycle phase transition • actin cytoskeleton organization • erythrocyte development • cell-cell adhesion • muscle contraction • actin filament organization • myofibril assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29766	50875
Ensembl	ENSG00000138594	ENSMUSG00000058587
UniProt	Q9NYL9	Q9JHJ0
RefSeq (mRNA)	NM_014547	NM_016963 NM_001357828
RefSeq (protein)	NP_055362	NP_058659 NP_001344757
Location (UCSC)	Chr 15: 51.83 – 51.95 Mb	Chr 9: 75.5 – 75.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

[5]

[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138594 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058587 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fischer, Robert S.; Yarmola, Elena G.; Weber, Kari L.; Speicher, Kaye D.; Speicher, David W.; Bubb, Michael R.; Fowler, Velia M. (2006-11-24). "Tropomodulin 3 Binds to Actin Monomers". Journal of Biological Chemistry. 281 (47): 36454–36465. doi:10.1074/jbc.M606315200. ISSN 0021-9258. PMID 17012745.
6. "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility (PDF Download Available)". ResearchGate. Retrieved 2017-03-28.
7. Cox PR, Zoghbi HY (Apr 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
8. "Entrez Gene: TMOD3 tropomodulin 3 (ubiquitous)".

Further reading

• Weber KL, Fischer RS, Fowler VM (2008). "Tmod3 regulates polarized epithelial cell morphology". J. Cell Sci. 120 (Pt 20): 3625–32. doi:10.1242/jcs.011445. PMID 17928307.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Fischer RS, Yarmola EG, Weber KL, et al. (2007). "Tropomodulin 3 binds to actin monomers". J. Biol. Chem. 281 (47): 36454–65. doi:10.1074/jbc.M606315200. PMID 17012745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Fischer RS, Fritz-Six KL, Fowler VM (2003). "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility". J. Cell Biol. 161 (2): 371–80. doi:10.1083/jcb.200209057. PMC 2172920. PMID 12707310.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.