MYH15

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.[5]

MYH15
Identifiers
Aliases	MYH15, myosin heavy chain 15
External IDs	OMIM: 609929 MGI: 3643515 HomoloGene: 18929 GeneCards: MYH15
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.13 Start 108,380,368 bp[1] End 108,529,322 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 49,057,486 bp[2] End 49,199,104 bp[2]
Gene ontology Molecular function • nucleotide binding • actin binding • cellular motor activity • ATP binding • calmodulin binding • actin filament binding • microtubule motor activity • microtubule binding Cellular component • cytoplasm • myosin filament • myofibril • myosin complex Biological process • extraocular skeletal muscle development • microtubule-based movement Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22989	667772
Ensembl	ENSG00000144821	ENSMUSG00000092009
UniProt	Q9Y2K3	E9Q264
RefSeq (mRNA)	NM_014981	NM_001166210
RefSeq (protein)	NP_055796	NP_001159682
Location (UCSC)	Chr 3: 108.38 – 108.53 Mb	Chr 16: 49.06 – 49.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

MYH15 is a slow-twitch myosin.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144821 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000092009 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
• Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Stedman HH, Kozyak BW, Nelson A, et al. (2004). "Myosin gene mutation correlates with anatomical changes in the human lineage". Nature. 428 (6981): 415–8. doi:10.1038/nature02358. PMID 15042088.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
• Bare LA, Morrison AC, Rowland CM, et al. (2007). "Five common gene variants identify elevated genetic risk for coronary heart disease". Genet. Med. 9 (10): 682–9. doi:10.1097/GIM.0b013e318156fb62. PMID 18073581.