KRT86

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.[5][6][7]

KRT86
Identifiers
AliasesKRT86, HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6, K86, keratin 86
External IDsOMIM: 601928 MGI: 109362 HomoloGene: 1717 GeneCards: KRT86
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.13Start52,249,300 bp[1]
End52,309,163 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3892

16679

Ensembl

ENSG00000170442

ENSMUSG00000067614

UniProt

O43790

P97861

RefSeq (mRNA)

NM_002284
NM_001320198

NM_010667

RefSeq (protein)

NP_001307127

NP_034797

Location (UCSC)Chr 12: 52.25 – 52.31 MbChr 15: 101.47 – 101.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000170442 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067614 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J (Aug 1997). "Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix". Nat Genet. 16 (4): 372–4. doi:10.1038/ng0897-372. PMID 9241275.
  6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. "Entrez Gene: KRT86 keratin 86".

Further reading


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