Keratin 34

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[5][6][7][8]

KRT34
Identifiers
Aliases	KRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34
External IDs	OMIM: 602763 MGI: 1309994 HomoloGene: 31083 GeneCards: KRT34
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,377,650 bp[1] End 41,382,403 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.38 cM Start 100,037,347 bp[2] End 100,041,554 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity Cellular component • intermediate filament • extracellular exosome • extracellular • cytosol Biological process • epidermis development • keratinization • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3885	16672
Ensembl	ENSG00000131737 ENSG00000262045	ENSMUSG00000043485
UniProt	O76011	Q9D646
RefSeq (mRNA)	NM_021013	NM_027563
RefSeq (protein)	NP_066293	NP_081839
Location (UCSC)	Chr 17: 41.38 – 41.38 Mb	Chr 11: 100.04 – 100.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[8]

See also

• 34βE12 (keratin 903)

References

1. ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
6. Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
7. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
8. "Entrez Gene: KRT34 keratin 34".

Further reading

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 46 (1): 11–5. PMID 16286979.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.