Tropomodulin 1

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.[5][6][7]

TMOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PKG, 4PKH, 4PKI, 4Z8G, 4Z94
Identifiers
Aliases	TMOD1, D9S57E, ETMOD, TMOD, tropomodulin 1
External IDs	OMIM: 190930 MGI: 98775 HomoloGene: 20701 GeneCards: TMOD1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 97,501,180 bp[1] End 97,601,743 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B1|4 24.49 cM Start 46,038,935 bp[2] End 46,116,032 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin filament binding • actin binding • tropomyosin binding Cellular component • membrane • COP9 signalosome • cytoskeleton • cytosol • cortical cytoskeleton • cytoplasm • sarcomere • myofibril • actin filament • striated muscle thin filament Biological process • adult locomotory behavior • lens fiber cell development • muscle filament sliding • pointed-end actin filament capping • muscle contraction • actin filament organization • myofibril assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7111	21916
Ensembl	ENSG00000136842	ENSMUSG00000028328
UniProt	P28289	P49813
RefSeq (mRNA)	NM_003275 NM_001166116	NM_021883
RefSeq (protein)	NP_001159588 NP_003266	NP_068683
Location (UCSC)	Chr 9: 97.5 – 97.6 Mb	Chr 4: 46.04 – 46.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136842 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028328 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S (Mar 1992). "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616–21. PMID 1370827.
6. Sung LA, Fan Y, Lin CC (Dec 1996). "Gene assignment, expression, and homology of human tropomodulin". Genomics. 34 (1): 92–6. doi:10.1006/geno.1996.0245. PMID 8661028.
7. "Entrez Gene: TMOD1 tropomodulin 1".

Further reading

• Ursitti JA, Fowler VM (1994). "Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons". J. Cell Sci. 107 (6): 1633–9. PMID 7962203.
• Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene". Biochem. Biophys. Res. Commun. 201 (2): 627–34. doi:10.1006/bbrc.1994.1747. PMID 8002995.
• Sussman MA, Bilak M, Kedes L, et al. (1994). "Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions". Exp. Cell Res. 209 (2): 388–91. doi:10.1006/excr.1993.1325. PMID 8262158.
• Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
• Vera C, Sood A, Gao KM, et al. (2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. Biochem. Biophys. 378 (1): 16–24. doi:10.1006/abbi.2000.1802. PMID 10871039.
• McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.
• Chu X, Thompson D, Yee LJ, Sung LA (2001). "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments". Gene. 256 (1–2): 271–81. doi:10.1016/S0378-1119(00)00327-9. PMID 11054557.
• Greenfield NJ, Fowler VM (2002). "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin". Biophys. J. 82 (5): 2580–91. doi:10.1016/S0006-3495(02)75600-2. PMC 1302047. PMID 11964245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction". Arch. Biochem. Biophys. 444 (2): 130–8. doi:10.1016/j.abb.2005.10.002. PMID 16297372.
• Kong KY, Kedes L (2006). "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres". J. Biol. Chem. 281 (14): 9589–99. doi:10.1074/jbc.M512064200. PMID 16434395.