DYNC1LI2

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene.[5][6]

DYNC1LI2
Identifiers
Aliases	DYNC1LI2, DNCLI2, LIC2, dynein cytoplasmic 1 light intermediate chain 2
External IDs	OMIM: 611406 MGI: 107738 HomoloGene: 4474 GeneCards: DYNC1LI2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 66,720,893 bp[1] End 66,751,609 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 104,417,680 bp[2] End 104,443,047 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • microtubule motor activity • nucleotide binding • cellular motor activity • ATP binding • dynein heavy chain binding Cellular component • cytoplasm • cytosol • membrane • dynein complex • microtubule • cytoskeleton • cytoplasmic dynein complex • kinetochore • lysosome • late endosome • centrosome Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • centrosome localization • ER to Golgi vesicle-mediated transport • microtubule cytoskeleton organization • microtubule-based movement • sister chromatid cohesion • transport • protein homooligomerization • cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1783	234663
Ensembl	ENSG00000135720	ENSMUSG00000035770
UniProt	O43237	Q6PDL0
RefSeq (mRNA)	NM_001286157 NM_006141 NM_001323955	NM_001013380
RefSeq (protein)	NP_001273086 NP_001310884 NP_006132 NP_006132.1	NP_001013398
Location (UCSC)	Chr 16: 66.72 – 66.75 Mb	Chr 8: 104.42 – 104.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135720 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035770 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
6. "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2".

Further reading

• Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995). "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases". J. Cell Sci. 108 (1): 17–24. PMID 7738094.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.