MYL6

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.[5][6][7][8]

MYL6
Identifiers
Aliases	MYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDs	OMIM: 609931 MGI: 109318 HomoloGene: 69080 GeneCards: MYL6
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,158,161 bp[1] End 56,163,496 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,490,860 bp[2] End 128,494,145 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • actin-dependent ATPase activity • calcium ion binding • structural constituent of muscle • cellular motor activity • GO:0001948 protein binding Cellular component • vesicle • cytosol • unconventional myosin complex • extracellular exosome • membrane • brush border • myosin complex • extracellular matrix Biological process • muscle contraction • skeletal muscle tissue development • muscle filament sliding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4637	17904
Ensembl	ENSG00000092841	ENSMUSG00000090841
UniProt	P60660	Q60605
RefSeq (mRNA)	NM_079425 NM_021019 NM_079423	NM_010860 NM_001317217 NM_001317218 NM_001317219 NM_001317220
RefSeq (protein)	NP_066299 NP_524147	NP_001304146 NP_001304147 NP_001304148 NP_001304149 NP_034990
Location (UCSC)	Chr 12: 56.16 – 56.16 Mb	Chr 10: 128.49 – 128.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000092841 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090841 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229.
6. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
7. Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. PMID 2722814.
8. "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle".

Further reading

• Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. PMID 8856505.
• Watanabe M, Kohri M, Takaishi M, et al. (2001). "Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells". Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 37 (1): 25–38. doi:10.1540/jsmr.37.25. PMID 11436981.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Fu ZY, Xie BT, Ma YT, Gong ZX (2006). "Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies". Acta Biochim. Biophys. Sin. (Shanghai). 38 (9): 625–32. doi:10.1111/j.1745-7270.2006.00203.x. PMID 16953301.