DYNLL2

DYNLL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	58,095,542 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	87,987,533 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cellular motor activity; • GO:0001948 protein binding; • ATP-dependent microtubule motor activity, plus-end-directed; • dynein intermediate chain binding; • dynein light intermediate chain binding; • cytoskeletal protein binding; • protein homodimerization activity; • protein heterodimerization activity; • scaffold protein binding;
Cellular component	• cytoplasm; • cytosol; • cell nucleus; • membrane; • ciliary tip; • centrosome; • microtubule; • cell membrane; • microtubule associated complex; • dynein complex; • cytoskeleton; • mitochondrion; • cilium; • myosin V complex; • cytoplasmic dynein complex; • myosin complex; • GO:0097483, GO:0097481 postsynaptic density; • postsynapse; • glutamatergic synapse;
Biological process	• microtubule-based process; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • ER to Golgi vesicle-mediated transport; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • macroautophagy; • intraciliary transport involved in cilium assembly; • transport along microtubule; • cilium morphogenesis; • positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; • sister chromatid cohesion; • transport;
	Sources:Amigo / QuickGO
Orthologs
	140735
	68097
	ENSG00000264364
	ENSMUSG00000020483
	Q96FJ2
	Q9D0M5
	NM_080677
	NM_001168471; NM_001168472; NM_026556
	NP_542408
	NP_001161943; NP_001161944; NP_080832
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.[5][6]

Interactions

DYNLL2 has been shown to interact with DLG4,[7] C12orf40,[8] DLGAP1,[7] MYO5A[7][9] and BMF.[9][10]

gollark: Ah. I see.

gollark: <@&198138780132179968> <@270035320894914560>/aus210 has stolen my (enchanted with Unbreaking something/Mending) elytra.I was in T79/i02p/n64c/pjals' base (aus210 wanted help with some code, and they live in the same place with some weird connecting tunnels) and came across an armor stand (it was in an area of the base I was trusted in - pjals sometimes wants to demo stuff to me or get me to help debug, and the claim organization is really odd). I accidentally gave it my neural connector, and while trying to figure out how to get it back swapped my armor onto it (turns out shiftrightclick does that). Eventually I got them both back, but while my elytra was on the stand aus210 stole it. I asked for it back and they repeatedly denied it.They have claimed:- they can keep it because I intentionally left it there (this is wrong, and I said so)- there was no evidence that it was mine so they can keep it (...)EDIT: valithor got involved and got them to actually give it back, which they did after ~10 minutes of generally delaying, apparently leaving it in storage, and dropping it wrong.

gollark: Someone had a problem with two mutually recursive functions (one was defined after the other), so I fixed that for them. Then I explained stack overflows and how that made their design (`mainScreen` calls `itemScreen` calls `mainScreen`...) problematic. Their suggested solution was to just capture the error and restart the program. Since they weren't entirely sure how to do *that*, their idea was to make it constantly ping their webserver and have another computer reboot it if it stopped.

gollark: potatOS is also secure <@!290217153293189120> ke

gollark: Probably.

References

GRCh38: Ensembl release 89: ENSG00000264364 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020483 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
"Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. UNITED STATES. 20 (12): 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. ISSN 0270-6474. PMC 6772433. PMID 10844022.
Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. United States. 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872.
Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

External links

Overview of all the structural information available in the PDB for UniProt: Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB.

Donner J, et al. (2008). "An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders". Biological Psychiatry. 64 (8): 672–680. doi:10.1016/j.biopsych.2008.06.002. PMC 2682432. PMID 18639233.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000264364 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020483 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16260502-5] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.

[entrez-6] "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".

[pmid10844022-7] Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. UNITED STATES. 20 (12): 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. ISSN 0270-6474. PMC 6772433. PMID 10844022.

[8] Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

[pmid11546872-9] Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. United States. 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872.

[pmid14561217-10] Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

DYNLL2

Interactions

References

Further reading

External links