Lidoflazine

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Lidoflazine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.020.285
Chemical and physical data
FormulaC30H35F2N3O
Molar mass491.627 g·mol−1
3D model (JSmol)
Melting point159 to 161 °C (318 to 322 °F)
Solubility in waterAlmost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
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Physical properties

Solubility at room temperature

Extracted from[1]

Solvent 0.01

N

0.1

N

% pH % pH
Hydrochloric Acid 0.4 3.0 0.7 1.9
Tartaric Acid 0.3 3.1 1.0 2.5
Citric Acid 0.3 3.1 0.5 2.5
Lactic Acid 0.2 3.4 0.7 2.9
Acetic Acid 0.1 3.5 0.4 3.8
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References

  1. Schaper WK, Xhoneux R, Jageneau AH, Janssen PA (May 1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". The Journal of Pharmacology and Experimental Therapeutics. 152 (2): 265–74. PMID 5944369.

Further reading

  • Schaper WK, Xhonneux R, Jageneau AH (November 1965). "Stimulation of the coronary collateral circulation by lidoflazine (R 7904)". Naunyn-Schmiedebergs Archiv Fur Experimentelle Pathologie und Pharmakologie. 252 (1): 1–8. doi:10.1007/bf00246424 (inactive 2020-05-29). PMID 4222721.
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