Trimethadione
Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.
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| Trade names | Tridione |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration | By mouth |
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| Bioavailability | High |
| Metabolism | Demethylated to dimethadione |
| Elimination half-life | 12–24 hours (trimethadione) 6–13 days (dimethadione) |
| Excretion | Renal |
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| ECHA InfoCard | 100.004.406  |
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| Formula | C6H9NO3 |
| Molar mass | 143.142 g·mol−1 |
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Fetal trimethadione syndrome
If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]
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References
- Teratology and Drug Use During Pregnancy Retrieved January 2007
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