Trimethadione
Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.
 | |
| Clinical data | |
|---|---|
| Trade names | Tridione |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy category |
|
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | High |
| Metabolism | Demethylated to dimethadione |
| Elimination half-life | 12–24 hours (trimethadione) 6–13 days (dimethadione) |
| Excretion | Renal |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.004.406  |
| Chemical and physical data | |
| Formula | C6H9NO3 |
| Molar mass | 143.142 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Fetal trimethadione syndrome
If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]
gollark: That would be good. I don't know what some of the American coast is meant to look like normally. Or Japan and Indonesia and such.
gollark: BRB, retasking orbital laser arrays.
gollark: Look at all that nice usable land in Antarctica.
gollark: Seems kind of cramped, although I guess you'd want them to exist.
gollark: The human did not agree to host tapeworms.
References
- Teratology and Drug Use During Pregnancy Retrieved January 2007
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.