Darodipine

Darodipine is an experimental calcium channel blocker that based on animal models may reduce neuronal cytoskeletal alterations during aging and in neurodegenerative disorders. Studies performed on rats have shown darodipine to have an effect on brain serotonergic systems. Darodipine increased the 5-HIAA/5-HT ratio within various parts of the brain.[1] Darodipine has also been shown to impair memory and learning processes on mice.[2]

Darodipine

Names
IUPAC name 4-(2,1,3-Benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Identifiers
CAS Number	72803-02-2
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2104154
ChemSpider	46790
PubChem CID	51701
UNII	N4AL7X96GL^Y
CompTox Dashboard (EPA)	DTXSID90223125
InChI InChI=1/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3 Key: QERUYFVNIOLCHV-UHFFFAOYAW
SMILES O=C(OCC)\C3=C(\N\C(=C(\C(=O)OCC)C3c1cccc2nonc12)C)C
Properties
Chemical formula	C19H21N3O5
Molar mass	371.393 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

• Isradipine, a structural isomer of darodipine

References

1. Gaggi, Renato (June–July 1995). "Effects of isradipine and darodipine on serotonergic system of the rat brain". Pharmacology, Biochemistry and Behavior. 51 (2): 183–187.
2. Lamberti, C. (Dec 1994). "Effects of the calcium-channel blockers darodipine and nimodipine on amnesia induced by three different hypoxic methods". Pharmacological Research. 30: 359.