Cinchocaine
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | topical, intravenous (for animal euthanasia) |
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| ECHA InfoCard | 100.001.484  |
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| Formula | C20H29N3O2 |
| Molar mass | 343.471 g·mol−1 |
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Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl.[3] It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
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See also
References
- Martindale, The Extra Pharmacopoeia, 30th ed, p1006
- Dibucaine
- "Proctosedyl ointment/suppositories (cinchocaine, hydrocortisone)". Netdoctor. June 2012. Retrieved 25 December 2019.
Further reading
- Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco. 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padron T, Lima AP, de Oliveira Ribeiro R (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitol Res. 99 (4): 317–20. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Pol Pharm. 62 (5): 369–79. PMID 16459486.
- Aroti, A.; Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment ". Journal of Chemical Education. 78 (6): 786–788. doi:10.1021/ed078p786.
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